Early in the first quarter, the Tigers made their mark on their Southeast Missouri State opponents.

In the Tigers' first possession, sophomore tailback Derrick Washington rushed for 5 yards for the Tigers first touchdown of the game.

About halfway through the first quarter, Washington helped the Tigers secure a second touchdown with a 22-yard run to the SEMO 3 yard line. Sophomore wide receiver Jeremy Maclin then made a 3-yard run for a touchdown to bring the score up to 14-0.

SEMO tried to get on the scoreboard with a field goal attempt from the 28-yard line. But that attempt was blocked by senior defensive lineman Ziggy Hood and the Tigers recovered on the MU 25-yard line.

At the end of the first quarter, Washington ran a 28-yard pass to score another touchdown for the Tigers, making the score 21-0.

Junior wide receiver Jared Perry started off the second quarter with a 28-yard run that led to a touchdown and put the score at 28-0 for the Tigers.

The Tigers continued to dominate when junior linebacker Sean Weatherspoon intercepted a pass from SEMO senior quarterback Houston Lillard at the MU 35-yard line. Weatherspoon ran the interception 65 yards for a touchdown, and the Tigers' lead increased to 35-0.

Washington scored his third touchdown with a 5-yard run about half through the second quarter to bring up the score 42-0, Tigers leading.

At the end of the second quarter, SEMO again attempted a field goal from the 28-yard line. But the ball went wide left, spot at the MU 25-yard line, and left SEMO off the scoreboard for the first half of the game.

In the third quarter, senior second-string quarterback Chase Patton stepped in.

Toward the end of the third quarter, senior placekicker Jeff Wolfert kicked 43-yard field goal so that Mizzou led 45-0.

At the top of the fourth quarter, SEMO put points on the scoreboard with a 31-yard field goal by junior kicker Doug Spada. Spada's field goal dashed hopes of a shutout for Mizzou, although the Tigers still led 45-3.

Mizzou answered Spada's field goal with another touchdown. Senior tailback Jimmy Jackson had a 17-yard run for a touchdown, making the score 52-3, Mizzou leading.

The remainder of the fourth quarter was a back and forth exchange of the ball by both teams. There was no additional scoring, and the final score of the first home game was 52-3 with Mizzou winning by a landslide.