Promising drug treats syndrome common in cancer patients

1 year 2 months 3 weeks ago Monday, July 24 2017 Jul 24, 2017 Monday, July 24, 2017 3:35:00 PM CDT July 24, 2017 in News
By: David Rothchild, KOMU 8 Reporter
loading

COLUMBIA – The University of Missouri is partnering with a Columbia-based company to fight a familiar condition in cancer patients.

The university's Veterinary Center is teaming up with biotechnical company Tensive Controls to test its drug that treats the effects of a syndrome called cachexia.

“Cachexia anorexia syndrome is a devastating end-stage of many different disease processes,” MU Associate Veterinary Professor Sandra Bechtel said. “What it leads to is a decline in appetite, then leading to lethargy, weight loss, and a decrease in muscle mass and an overall decline in quality of life.”

“Our drug acts to counteract those affects by enhancing weight and increasing appetite,” Tensive Controls President Ken Gruber said.

Bechtel said about 50 percent of people in late-stage cancer experience these symptoms of cachexia. She also said dogs develop diseases very similarly to humans, which is why Tensive Controls is currently testing the drug on canines.

“We have dogs that are sick and we want to make them feel better,” Bechtel said. “And we have a clinical trial that can not only make them feel better, but can help us make people feel better in the future.”

Tensive Controls Lab Director Brittany Angle put her dog, Bubba, in the drug trial in August of 2016 when he started to show signs of cachexia.

“I enrolled Bubba in this trial because I noticed he gradually started losing a lot of weight,” Angle said. “He became very bony, he wasn’t eating well, he was hardly drinking any water, and he really just didn’t want to do anything at all.”

After taking the drug for nine months, Angle said Bubba gained weight and muscle mass, and his body condition and appetite improved.

“Within three or four days of being on the drug I noticed an immediate improvement in appetite, and in water intake, and activity level,” Angle said. “It is remarkable how quickly it works. Weight gain was a little more gradual, but he was happy, he was eating – I was happy.”

Bechtel said the other two dogs in the provisonal MU trial also showed similar improvements on the drug, and Gruber said he hopes the canine trial can end in about two years.

"Once we finish the veterinary trial, we’ll be able to have a body of evidence to support our human application as well," Gruber said.

As for potential side effects, Bechtel said the only major one they have found so far is a change in fur color.

More News

Grid
List
(CNN) -- President Donald Trump announced Saturday that the US is pulling out of the landmark Intermediate-Range Nuclear Forces Treaty... More >>
7 hours ago Saturday, October 20 2018 Oct 20, 2018 Saturday, October 20, 2018 5:11:00 PM CDT October 20, 2018 in News
COLUMBIA – Nineteen members of Missouri Task Force One returned to Boone County Fire Protection District headquarters Saturday morning after... More >>
9 hours ago Saturday, October 20 2018 Oct 20, 2018 Saturday, October 20, 2018 3:16:00 PM CDT October 20, 2018 in News
SPRINGFIELD (AP) — A man has been criminally charged days after a woman's body was found near Fellows Lake at... More >>
10 hours ago Saturday, October 20 2018 Oct 20, 2018 Saturday, October 20, 2018 1:58:08 PM CDT October 20, 2018 in News
SPRINGFIELD (AP) — A Springfield woman who killed her live-in boyfriend with a crowbar in 2017 has been sentenced to... More >>
11 hours ago Saturday, October 20 2018 Oct 20, 2018 Saturday, October 20, 2018 1:48:36 PM CDT October 20, 2018 in News
ST. LOUIS (AP) — A restored St. Louis prairie of native grasses and flowers is in bloom, but the nature... More >>
15 hours ago Saturday, October 20 2018 Oct 20, 2018 Saturday, October 20, 2018 8:50:24 AM CDT October 20, 2018 in News
HERMANN - One person was killed and several people were injured in a crash involving a trolley, according to the... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 11:57:00 PM CDT October 19, 2018 in News
COLUMBIA - Sen. Claire McCaskill spoke about health care in Columbia on Friday at Laborers Local 955, as part of... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 7:35:00 PM CDT October 19, 2018 in News
COLUMBIA - After realizing the underrepresentation of Hispanic business owners in mid-Missouri, three Hispanic professionals established a group of 12... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 5:49:00 PM CDT October 19, 2018 in News
COLUMBIA - This is the last week of the regular season and it's a cold one. Our game of... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 5:20:00 PM CDT October 19, 2018 in Friday Night Fever
COLUMBIA - Two Midwest companies issued separate food recalls this week for bacterial contamination concerns. Hy-Vee said its supplier,... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 4:53:00 PM CDT October 19, 2018 in News
CAMDEN (AP) — Toxicology tests show that a boater was drunk when he slammed into a bluff at Missouri's Lake... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 3:41:35 PM CDT October 19, 2018 in News
COLUMBIA - The Legion of Black Collegians and the FourFront Marginalized Student Council held a solidarity walk Friday to show... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 3:39:00 PM CDT October 19, 2018 in News
JEFFERSON CITY - The Missouri State Medical Association (MSMA), along with multiple medical associations, reaffirmed their opposition to the three... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 2:50:00 PM CDT October 19, 2018 in News
JEFFERSON CITY - For the fourth consecutive year, Project Homeless Connect provided services Friday for people who are experiencing homelessness... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 2:39:00 PM CDT October 19, 2018 in News
DES MOINES, Iowa (AP) — The Mega Millions jackpot has soared to an estimated $1 billion, as the second-largest lottery... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 12:10:00 PM CDT October 19, 2018 in News
JEFFERSON CITY - Police want the public's help finding a man who allegedly ran from a traffic stop after hurting... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 11:42:00 AM CDT October 19, 2018 in News
COLUMBIA - Two MU residence halls and an atrium were officially dedicated on Friday honoring three former MU students. Lucile... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 10:09:00 AM CDT October 19, 2018 in News
WASHINGTON (AP) — Just 1 in 4 people thinks Brett Kavanaugh was completely honest when as a Supreme Court nominee... More >>
1 day ago Friday, October 19 2018 Oct 19, 2018 Friday, October 19, 2018 9:58:13 AM CDT October 19, 2018 in News
Columbia, MO
Broken Clouds 38°
1am 37°
2am 36°
3am 35°
4am 34°